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Challenges Associated with Using Circulating Free DNA as a
Liquid Biopsy Tool
One of the Circulating
Free DNA main challenges associated with using circulating free DNA (cfDNA)
as a liquid biopsy tool is the potential for false positives or false
negatives. The detection and analysis of cfDNA can be complex, and errors in
interpretation can occur. This can lead to incorrect diagnoses or treatment
decisions.
Another challenge is the need for highly sensitive and specific detection
methods. cfDNA is present at low levels in circulation, making it difficult to
isolate and analyze accurately. Improvements in technology are needed to
enhance sensitivity and specificity, ensuring reliable results.
Furthermore, there are challenges related to sample collection and storage.
Proper handling of blood samples is crucial to preserve the integrity of cfDNA.
Any contamination or degradation during processing could affect the accuracy of
subsequent analyses.
The heterogeneity of tumors also poses a challenge when using cfDNA as a liquid
biopsy tool. Different regions within a tumor may have varying amounts or types
of genetic alterations, leading to incomplete representation in cfDNA analysis.
Cost-effectiveness is an ongoing concern. Implementing AZ News testing on a large
scale may require significant financial resources, limiting its accessibility
in certain healthcare settings.
Addressing these challenges will be key to fully harnessing the potential of
circulating free DNA as a liquid biopsy tool for cancer diagnosis and
monitoring. Ongoing research and technological advancements will play vital
roles in overcoming these obstacles and improving patient outcomes.
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